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Article

Loss of the serum response factor in the dopamine system leads to hyperactivity

11 Mar 2010

Abstract excerpt

The serum response factor (SRF) is a key regulator of neural development and cellular plasticity, which enables it to act as a regulator of long-term adaptations in neurons. Here we performed a comprehensive analysis of SRF function in the murine dopamine system. We found that loss of SRF in dopaminoceptive, but not dopaminergic, neurons is responsible for the development of a hyperactivity syndrome,...

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PMID: 20223941
DOI: 10.1096/fj.09-151423

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