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Modeling Patient-Specific CAR-T Cell Dynamics: Multiphasic Kinetics Via Phenotypic Differentiation

2022-09-23

Abstract excerpt

Chimeric Antigen Receptor (CAR)-T cell immunotherapy revolutionized cancer treatment and consists of the genetic modification of T lymphocytes with a CAR gene, aiming to increase their ability to recognize and kill antigen-specific tumor cells. The dynamics of CAR-T cell responses in patients presents a multiphasic kinetics with distribution, expansion, contraction, and persistence phases. The characteristics and...

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Literature Corpus work
f87d5ff7-50d0-526b-ac5a-1683d15c8ad9
DOI
10.20944/preprints202209.0359.v1
Open publication

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Modeling Patient-Specific CAR-T Cell Dynamics: Multiphasic Kinetics Via Phenotypic DifferentiationDOI 10.20944/preprints202209.0359.v1
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