Article

Mechanisms of Resistance to CAR-T cell Immunotherapy: Insights from a Mathematical Model

2023-05-02

Abstract excerpt

Chimeric Antigen Receptor (CAR)-T cell therapy long-term follow-up studies revealed non-durable remissions in a significant number of patients. Some of the mechanisms underlying these relapses include poor CAR T cell cytotoxicity or persistence, as well as antigen loss or lineage switching in tumor cells. In order to investigate how antigen-mediated resistance mechanisms affect therapy outcomes, we develop a mathe...

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Literature Corpus work: 601efb6b-c475-5f65-9a19-182c7ba1bbc2
DOI: 10.1101/2023.05.01.538974

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