Article

Healthy B cells: allies or adversaries of CAR-T cell immunotherapy?

2024-11-11

Abstract excerpt

Chimeric antigen receptor (CAR)-T cell immunotherapy has achieved significant success against various haematological cancers, including B-cell malignancies. Its efficacy against B-cell cancers is influenced by the presence of healthy B-cells expressing the target antigen, and B-cell aplasia (BCA) serves as an indicator of successful therapy outcome. However, the precise influence of healthy B-cells on the in vivo...

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Literature Corpus work: 571b6ec9-ab40-5287-b6ef-a467fe226140
DOI: 10.1101/2024.11.08.622644

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