Article

CAR‐T‐cell products in solid tumors: Progress, challenges, and strategies

2024-04-01

Abstract excerpt

Abstract T cells engineered to express chimeric antigen receptors (CARs) with specificity toward tumor cells have led to promising outcomes in patients with hematological malignancies. Nevertheless, the application of CAR‐T cell therapy in solid tumors encounters several obstacles. These include tumor heterogeneity and immune escape, T cell exhaustion and restricted infiltration into the tumors that affect the the...

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Literature Corpus work: 66956c96-4185-5348-8bc4-b82071908b1d
DOI: 10.1002/inmd.20230047

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