Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deconvolution of clinical variance in CAR-T cell pharmacology and response

27 Feb 2023

Abstract excerpt

Chimeric antigen receptor T cell (CAR-T) expansion and persistence vary widely among patients and predict both efficacy and toxicity. However, the mechanisms underlying clinical outcomes and patient variability are poorly defined. In this study, we developed a mathematical description of T cell responses wherein transitions among memory, effector and exhausted T cell states are coordinately regulated by tumor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Viral Infectious Diseases and Gene Expression in Insects

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 36849828
DOI: 10.1038/s41587-023-01687-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deconvolution of clinical variance in CAR-T cell pharmacology and responsePMID 36849828Read ↗

CAR+ and CAR− T cells share a differentiation trajectory into an NK-like subset after CD19 CAR T cell infusion in patients with B cell malignanciesSemantic proximity Read ↗

Single-Cell RNA Analysis Reveals Cell-Intrinsic Functions of CAR T Cells Correlating with Response in a Phase II Study of Lymphoma PatientsSemantic proximity Read ↗

A longitudinal single-cell atlas to predict outcome and toxicity after BCMA-directed CAR T cell therapy in multiple myelomaSemantic proximity Read ↗

Distinct cellular dynamics associated with response to CAR-T therapy for refractory B-cell lymphomaSemantic proximity Read ↗

An open CAR-T single-cell atlas to enable in-depth characterization and rational engineering of CAR-T productsSemantic proximity Read ↗

Functional diversification and dynamics of CAR-T cells in patients with B-ALLSemantic proximity Read ↗

CAR<sup>+</sup> and CAR<sup>-</sup> T cells differentiate into an NK-like subset that is associated with increased inflammatory cytokines following infusionSemantic proximity Read ↗

Modeling Patient-Specific CAR-T Cell Dynamics: Multiphasic Kinetics via Phenotypic DifferentiationSemantic proximity Read ↗

Integrative single-cell multi-omics of CD19-CAR <sup>pos</sup> and CAR <sup>neg</sup> T cells suggest drivers of immunotherapy response in B-cell neoplasiasSemantic proximity Read ↗

Modeling Patient-Specific CAR-T Cell Dynamics: Multiphasic Kinetics Via Phenotypic DifferentiationSemantic proximity Read ↗

CAR+ and CAR- T cells differentiate into an NK-like subset that is associated with increased inflammatory cytokines following infusionSemantic proximity Read ↗

Common trajectories of highly effective CD19-specific CAR T cells identified by endogenous T cell receptor lineagesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.