Article

Global transcriptome analysis identifies nicotinamide metabolism to play key roles in IFN-γ and nitric oxide modulated responses

2025-01-21

Abstract excerpt

Interferon-gamma (IFN-γ) is a key regulator of immune responses. A hallmark of the IFN-γ response is inducible nitric oxide (NO) production, driven primarily by nitric oxide synthase 2 (NOS2). In this study, we investigated the influence of NO on the IFN-γ-induced transcriptomic and metabolic changes in the RAW 264.7 macrophage cell line. IFN-γ activation led to NO-dependent lactate production and lower cell survi...

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Literature Corpus work: f82928f0-75ea-5b21-9ed5-f6365b6df836
DOI: 10.1101/2025.01.17.633516

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