Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Proteome Profiling of RNF213 Depleted Cells Reveals Nitric Oxide Regulator DDAH1 Antilisterial Activity.

Frontiers in cellular and infection microbiology - 1 Jan 2021

Martina Lia, Asselman Caroline, Thery Fabien, Boucher Katie, Delhaye Louis, Maia Teresa M, Dermaut Bart, Eyckerman Sven, Impens Francis

Abstract excerpt

RNF213 is a large, poorly characterized interferon-induced protein. Mutations in RNF213 are associated with predisposition for Moyamoya disease (MMD), a rare cerebrovascular disorder. Recently, RNF213 was found to have broad antimicrobial activity in vitro and in vivo, yet the molecular mechanisms behind this function remain unclear. Using mass spectrometry-based proteomics and validation by real-time PCR we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphatases
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Moyamoya Disease

Share to Nitric Oxide

Share to Proteome

Share to Ubiquitin-Protein Ligases

Source

Open in PubMed Open full text

Identifiers

PMID: 34804992
DOI: 10.3389/fcimb.2021.735416
PMCID: PMC8595287

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Proteome Profiling of RNF213 Depleted Cells Reveals Nitric Oxide Regulator DDAH1 Antilisterial Activity.PMID 34804992Read ↗

The emerging role of E3 ubiquitin ligase RNF213 as an antimicrobial host determinantSemantic proximity Read ↗

Novel Multifaceted Roles for RNF213 Protein.Semantic proximity Read ↗

Moyamoya disease susceptibility gene RNF213 links inflammatory and angiogenic signals in endothelial cellsSemantic proximity Read ↗

Loss of mitochondrial ClpP, Lonp1, and Tfam triggers transcriptional induction of Rnf213, a susceptibility factor for moyamoya disease.Semantic proximity Read ↗

Identification of diagnostic markers for moyamoya disease by combining bulk RNA-sequencing analysis and machine learningSemantic proximity Read ↗

Moyamoya disease emerging as an immune-related angiopathy.Semantic proximity Read ↗

Moyamoya disease patient mutations in the RING domain of RNF213 reduce its ubiquitin ligase activity and enhance NFκB activation and apoptosis in an AAA+ domain-dependent manner.Semantic proximity Read ↗

Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanismSemantic proximity Read ↗

RNF213 loss of function reshapes vascular transcriptome and spliceosome leading to disrupted angiogenesis and aggravated vascular inflammatory responsesSemantic proximity Read ↗

RNF213 and cardiovascular disease: A review of histopathological, genetic perspectives, and potential molecular mechanisms.Semantic proximity Read ↗

RNF213 loss of function reshapes vascular transcriptome and spliceosome leading to disrupted angiogenesis and aggravated vascular inflammatory responsesSemantic proximity Read ↗

Global transcriptome analysis identifies nicotinamide metabolism to play key roles in IFN-γ and nitric oxide modulated responsesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.