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Article

Interferon-beta-1b-induced short- and long-term signatures of treatment activity in multiple sclerosis

19 Jun 2012

Abstract excerpt

Interferon beta (IFNβ) reduces disease burden in relapsing-remitting multiple sclerosis (MS) patients. In this study, IFNβ-1b-treated MS patient gene expression profiles and biological knowledgebases were integrated to study IFNβ's pleiotropic mechanisms of action. Genes involved in immune regulation, mitochondrial fatty acid metabolism and antioxidant activity were discovered. Plausible mediators of neuronal...

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PMID: 22711062
DOI: 10.1038/tpj.2012.27

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