Article

A human cytokine response atlas to reconstruct underlying gene regulatory networks

2026-07-29

Abstract excerpt

Circulating cytokines encode immune state, yet their pleiotropy and cell-type specificity make constructing a unified atlas of immune cell responses to them challenging. Here, I transformed a single-cell atlas of approximately 10 million human peripheral blood mononuclear cells from 12 donors exposed to 90 cytokines into a multiscale model of cytokine response. A GPU-accelerated implementation of dimension-scalabl...

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Literature Corpus work: 7b0eeb2b-4647-5e76-ac66-dab5a32a23e5
DOI: 10.64898/2026.07.27.740961

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