Article

Rewired NAD <sup>+</sup> metabolism promotes NF-κB-mediated oxidative stress and disrupts lipid homeostasis in liver fibrosis progression

2025-08-08

Abstract excerpt

<h4>ABSTRACT</h4> Chronic liver fibrosis significantly increases the risk of hepatocellular carcinoma (HCC), a leading cause of cancer-related deaths. However, the molecular mechanisms linking fibrosis to inflammation-associated HCC development remain unclear, complicating early diagnosis and intervention. In this study, we employ multi-omics analyses, including untargeted and targeted metabolomics, lipidomics, a...

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Literature Corpus work: 02752bcf-dcbd-57af-8b64-e6687e16e321
DOI: 10.1101/2025.08.06.668888

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Rewired NAD <sup>+</sup> metabolism promotes NF-κB-mediated oxidative stress and disrupts lipid homeostasis in liver fibrosis progressionDOI 10.1101/2025.08.06.668888Read

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