Article

Cytoplasmic NAD/H synthesis via NRK1 controls CD4+ T cell ROS homeostasis, regulating inflammatory capacity and promoting survival

2024-10-07

Abstract excerpt

<title>Abstract</title> <p>T cell metabolism increases upon activation, underpinning immune effector functions. Nicotinamide adenine dinucleotide (NAD/H) is an essential redox cofactor for glycolysis and mitochondrial substrate oxidation. It is also phosphorylated to NADP/H, which regulates reactive oxygen species (ROS) abundance. NAD/H levels increase upon T cell activation, but synthesis pathways and implicatio...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4603ceb2-d73c-5a19-bc7e-d85ffd206d14
DOI: 10.21203/rs.3.rs-5139488/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cytoplasmic NAD/H synthesis via NRK1 controls CD4+ T cell ROS homeostasis, regulating inflammatory capacity and promoting survivalDOI 10.21203/rs.3.rs-5139488/v1Read

NAD-Biosynthetic and Consuming Enzymes as Central Players of Metabolic Regulation of Innate and Adaptive Immune Responses in CancerSemantic proximity Read

The balance between NAD+ biosynthesis and consumption in ageingSemantic proximity Read

Dihydronicotinamide Riboside Is a Potent NAD+ Precursor Promoting a Pro-Inflammatory Phenotype in Macrophages.Semantic proximity Read

Decoding NAD+ Metabolism in COVID-19: Implications for Immune Modulation and TherapySemantic proximity Read

Targeting NAD+ metabolism: dual roles in cancer treatmentSemantic proximity Read

Extreme Vulnerability of IDH1 Mutant Cancers to NAD+ Depletion.Semantic proximity Read

NAD+ Degrading Enzymes, Evidence for Roles During InfectionSemantic proximity Read

NF-κB-inducing kinase maintains T cell metabolic fitness in antitumor immunity.Semantic proximity Read

Re-equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction.Semantic proximity Read

Metabolic regulation of NK cell antiviral functions during cytomegalovirus infectionSemantic proximity Read

Identification and Validation of Nicotinamide metabolism-Related Gene Signatures as a Novel Prognostic Model for hepatocellular carcinomaSemantic proximity Read

Global transcriptome analysis identifies nicotinamide metabolism to play key roles in IFN-γ and nitric oxide modulated responsesSemantic proximity Read