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Article

Extracellular nicotinamide phosphoribosyltransferase (NAMPT) promotes M2 macrophage polarization in chronic lymphocytic leukemia.

Blood - 1 Jan 2015

Audrito Valentina, Serra Sara, Brusa Davide, Mazzola Francesca, Arruga Francesca, Vaisitti Tiziana, Coscia Marta, Maffei Rossana, Rossi Davide, Wang Tao, Inghirami Giorgio, Rizzi Menico, Gaidano Gianluca, Garcia Joe G N, Wolberger Cynthia, Raffaelli Nadia, Deaglio Silvia

Abstract excerpt

Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme in nicotinamide adenine dinucleotide biosynthesis. In the extracellular compartment, it exhibits cytokine-/adipokinelike properties, suggesting that it stands at the crossroad between metabolism and inflammation. Here we show that both intracellular and extracellular NAMPT levels are increased in cells and plasma of chronic lymphocytic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25368373
DOI: 10.1182/blood-2014-07-589069

Genes

NAMPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Extracellular nicotinamide phosphoribosyltransferase (NAMPT) promotes M2 macrophage polarization in chronic lymphocytic leukemia.PMID 25368373Read ↗

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