Article

The immune profile of circulating autoreactive CD4 T cells is imprinted through tissue activation during autoimmune liver diseases

2024-03-29

Abstract excerpt

Autoimmune liver diseases (AILD) are immune-mediated disorders in which CD4 T cells play a central role. However, the link between circulating self-antigen-specific CD4 T cells and the targeted tissue has not been extensively studied in AILD. We hypothesized that circulating autoreactive CD4 T cells were clonally and functionally related to dominant intra-hepatic pathogenic CD4 T cell clones. Single cell transcrip...

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Literature Corpus work: f7fa2349-dabc-51a1-958f-57fd90a09ab2
DOI: 10.1101/2024.03.26.586770

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