Article

Integrative molecular profiling of autoreactive CD4 T cells in autoimmune hepatitis

2020-01-07

Abstract excerpt

<h4>Background & Aims</h4> In most autoimmune disorders, crosstalk of B cells and CD4 T cells results in the accumulation of autoantibodies. In autoimmune hepatitis (AIH), the presence of anti-Soluble Liver Antigen (SLA or SepSecs) autoantibodies is associated with significantly reduced overall survival, but the associated autoreactive CD4 T cells have not been characterized yet. Here we isolated and deeply chara...

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Literature Corpus work: fb32f052-e965-53a6-bcac-1d96154bceac
DOI: 10.1101/2020.01.06.895938

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