Back to search

Article

Accumulation of PD-1+ TIGIT+ T cells in the liver after local antigen reactivity and during autoimmune hepatitis

2025-09-02

Abstract excerpt

<h4>Summary</h4> In autoimmune hepatitis (AIH), hepatocellular damage is linked to an accumulation of autoreactive T cells in the liver of patients, but how these cells emerge in the tissue remains unclear. Here we used a mouse model based on recombination-dependent inducible expression of influenza A hemagglutinin (HA) by hepatocytes to investigate initiation of liver antigen-specific response. Our study reveale...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
23ffb6b8-75e9-50af-b467-31b01ec56400
DOI
10.1101/2025.08.29.672936
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Accumulation of PD-1+ TIGIT+ T cells in the liver after local antigen reactivity and during autoimmune hepatitisDOI 10.1101/2025.08.29.672936
The immune profile of circulating autoreactive CD4 T cells is imprinted through tissue activation during autoimmune liver diseasesSemantic proximity
Effects and regulation of autoreactive CD8+ T cells in a transgenic mouse model of autoimmune hepatitis.Semantic proximity
Single cell profiling of circulating autoreactive CD4 T cells from patients with autoimmune liver diseases suggests tissue imprintingSemantic proximity
Tissue-Resident Memory T Cells in the Liver-Unique Characteristics of Local Specialists.Semantic proximity
Adaptive immunity in autoimmune hepatitis.Semantic proximity
Genetic predisposition and environmental danger signals initiate chronic autoimmune hepatitis driven by CD4+ T cells.Semantic proximity
Antigen-Specific Immunotherapy for Treatment of Autoimmune Liver Diseases.Semantic proximity
Plasma proteomic analysis of autoimmune hepatitis in an improved AIH mouse modelSemantic proximity
Recently primed CD8+ T cells entering the liver induce hepatocytes to interact with naïve CD8+ T cells in the mouse.Semantic proximity
Type 2 autoimmune hepatitis murine model: the influence of genetic background in disease development.Semantic proximity
High expression of CD38 and MHC class II on CD8 <sup>+</sup> T cells during severe influenza disease reflects bystander activation and trogocytosisSemantic proximity
The influence of genetic predisposition and autoimmune hepatitis inducing antigens in disease development.Semantic proximity
Select a neighboring publication to make it the new centre.