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Article

B Cell Activation and Escape of Tolerance Checkpoints: Recent Insights from Studying Autoreactive B Cells.

Cells - 13 May 2021

Bonasia Carlo G, Abdulahad Wayel H, Rutgers Abraham, Heeringa Peter, Bos Nicolaas A

Abstract excerpt

Autoreactive B cells are key drivers of pathogenic processes in autoimmune diseases by the production of autoantibodies, secretion of cytokines, and presentation of autoantigens to T cells. However, the mechanisms that underlie the development of autoreactive B cells are not well understood. Here, we review recent studies leveraging novel techniques to identify and characterize (auto)antigen-specific B cells. The...

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Identifiers

PMID: 34068035
DOI: 10.3390/cells10051190
PMCID: PMC8152463

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