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Article

Cutting Edge: Molecular Portrait of Human Autoimmune Disease

1 Jul 2002

Abstract excerpt

Autoimmune diseases affect 3-5% of the population, are mediated by the immune response to self-Ags, and are characterized by the site of tissue destruction. We compared expression levels of >4,000 genes in PBMC of control individuals before and after immunization to those of individuals with four distinct autoimmune diseases. The gene expression profile of the normal immune response exhibits coordinate changes in...

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PMID: 12077221
DOI: 10.4049/jimmunol.169.1.5

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