Article

MYD88 mutations in clonal hematopoiesis promote inflammation and hematopoietic stem cell expansion

2025-06-25

Abstract excerpt

Clonal hematopoiesis of indeterminate potential (CHIP) is characterized by expansion of mutant hematopoietic stem and progenitor cells (HSPCs) and an increased risk of chronic diseases and cancers. While mutations in DNMT3A , TET2 , and ASXL1 are common in CHIP, the contribution of less frequent gene mutations is not well understood. Here, we report MYD88 mutations, including lymphoma-associated and novel vari...

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Literature Corpus work: f7f26fc9-96ad-5b23-a0da-160bd5c5bfc8
DOI: 10.1101/2025.06.19.660202

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