Article
Clinical relevance of clonal hematopoiesis in persons aged ≥80 years.
Blood - 25 Nov 2021
Rossi Marianna, Meggendorfer Manja, Zampini Matteo, Tettamanti Mauro, Riva Emma, Travaglino Erica, Bersanelli Matteo, Mandelli Sara, Antonella Galbussera Alessia, Mosca Ettore, Saba Elena, Chiereghin Chiara, Manes Nicla, Milanesi Chiara, Ubezio Marta, Morabito Lucio, Peano Clelia, Soldà Giulia, Asselta Rosanna, Duga Stefano, Selmi Carlo, De Santis Maria, Malik Karolina, Maggioni Giulia, Bicchieri Marilena, Campagna Alessia, Tentori Cristina A, Russo Antonio, Civilini Efrem, Allavena Paola, Piazza Rocco, Corrao Giovanni, Sala Claudia, Termanini Alberto, Giordano Laura, Detoma Paolo, Malabaila Aurelio, Sala Luca, Rosso Stefano, Zanetti Roberto, Saitta Claudia, Riva Elena, Condorelli Gianluigi, Passamonti Francesco, Santoro Armando, Sole Francesc, Platzbecker Uwe, Fenaux Pierre, Bolli Niccolò, Castellani Gastone, Kern Wolfgang, Vassiliou George S, Haferlach Torsten, Lucca Ugo, Della Porta Matteo G
Abstract excerpt
Clonal hematopoiesis of indeterminate potential (CHIP) is associated with increased risk of cancers and inflammation-related diseases. This phenomenon becomes common in persons aged ≥80 years, in whom the implications of CHIP are not well defined. We performed a mutational screening in 1794 persons aged ≥80 years and investigated the relationships between CHIP and associated pathologies. Mutations were observed...
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