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Article

Clonal hematopoiesis of indeterminate potential: a multisystem hub bridging hematopoietic dysfunction with non-hematopoietic diseases.

Military Medical Research - 14 Oct 2025

Zhang Jing-Lei, Tong Shuo-Lan, Zhuang Qi-Qi, Jin Sheng-Jie, Li Jia-Qiu, Sun Jie

Abstract excerpt

Clonal hematopoiesis of indeterminate potential (CHIP), driven by leukemia-related somatic mutations in hematopoietic stem cells, previously recognized as a major risk factor for hematological malignancies, has now emerged as a potent risk factor for chronic inflammation and diverse non-hematologic diseases. CHIP-associated DNA methyltransferase 3 alpha (DNMT3A), tet methylcytosine dioxygenase 2 (TET2), and...

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Source

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Identifiers

PMID: 41088446
DOI: 10.1186/s40779-025-00654-8
PMCID: PMC12519836

Genes

ASXL1
DNMT3A
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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