Article

Rac guanine nucleotide exchange factors promoting Lgl1 phosphorylation in glioblastoma

2020-12-02

Abstract excerpt

<h4>ABSTRACT</h4> The protein Lgl1 has key roles in the regulation of cell polarity. We have shown that Lgl1 is inactivated by hyperphosphorylation in glioblastoma as a consequence of PTEN loss and aberrant activation of the PI 3-kinase pathway; this contributes to glioblastoma pathogenesis both by promoting invasion and repressing glioblastoma cell differentiation. Lgl1 is phosphorylated by atypical protein kin...

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Literature Corpus work: f7e37f96-2007-5bab-b15a-bd5a90111e7e
DOI: 10.1101/2020.12.01.406538

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