Article

ANALYSIS OF THE PHOSPHORYLATION NETWORKS CHARACTERIZING DISTINCT PHENOTYPIC STATES IN GLIOBLASTOMA CELL POPULATIONS

2025-08-27

Abstract excerpt

<h4>ABSTRACT</h4> Cancer cells, including the most aggressive brain cancer, glioblastoma, can exhibit a high degree of phenotypic plasticity. However, it is not well understood whether and how distinct phenotypic states might be associated with or driven by specific signaling processes. Here, we use a novel approach to the identification of phenotype-specific signaling networks in cells undergoing the Go-or-Grow...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 065aaaf7-06eb-52e5-add2-01f4142f37de
DOI: 10.1101/2025.08.22.671611

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ANALYSIS OF THE PHOSPHORYLATION NETWORKS CHARACTERIZING DISTINCT PHENOTYPIC STATES IN GLIOBLASTOMA CELL POPULATIONSDOI 10.1101/2025.08.22.671611Read

Network Analyses of Brain Tumor Patients’ Multiomic Data Reveals Pharmacological Opportunities to Alter Cell State TransitionsSemantic proximity Read

Uncovering the signaling networks of disseminated glioblastoma cells <i>in vivo</i> with INSIGHTSemantic proximity Read

Network Analyses of Brain Tumor Patients’ Multiomic Data Reveals Pharmacological Opportunities to Alter Cell State TransitionsSemantic proximity Read

Single-Cell Phosphoproteomics Resolves Adaptive Signaling Dynamics and Informs Targeted Combination Therapy in Glioblastoma.Semantic proximity Read

Single-Cell Multiomic Profiling Uncovers Radiation Dosage-Sensitive, Cluster-Specific Regulatory Dynamics in GlioblastomaSemantic proximity Read

Quantitative single cell heterogeneity profiling of patient derived tumor initiating gliomaspheres reveals unique signatures of drug response and malignancySemantic proximity Read

Identification of Injury-Response State Determinants in Glioblastoma Stem CellsSemantic proximity Read

Targeting Glioblastoma Cell State Plasticity for Enhanced Therapeutic EfficacySemantic proximity Read

High risk glioblastoma cells revealed by machine learning and single cell signaling profilesSemantic proximity Read

JARID2 facilitates transcriptional reprogramming in glioblastoma in response to standard treatmentSemantic proximity Read

Intratumoral MAPK and PI3K signaling pathway heterogeneity in glioblastoma tissue correlates with selective CREB signaling and specific functional gene signaturesSemantic proximity Read

Cooperativity between MAPK and PI3K signaling activation is required for glioblastoma pathogenesisSemantic proximity Read