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Article

Knockdown of PREX2a inhibits the malignant phenotype of glioma cells.

Molecular medicine reports - 1 Mar 2016

Liu Liang, Liu Zhixiong, Wang Hao, Chen Long, Ruan Fuqiang, Zhang Jihui, Hu Yi, Luo Hengshan, Wen Shuai

Abstract excerpt

Glioma is the most common type of malignant brain tumor. Phosphatidylinositol‑3,4,5‑trisphosphate‑dependent Rac exchange factor 2a (PREX2a), which is a regulator of the small guanosine triphosphatase Rac, has previously been identified as an oncoprotein that inhibits phosphatase and tensin homolog deleted on chromosome 10 (PTEN) activity. However, the role of PREX2a in the regulation of the malignant phenotype of...

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Identifiers

PMID: 26795161
DOI: 10.3892/mmr.2016.4799

Genes

PTEN

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