Article

mTORC2 Interactome and Localization Determine Aggressiveness of High-Grade Glioma Cells through Association with Gelsolin

2022-10-13

Abstract excerpt

<h4>ABSTRACT</h4> The mTOR complex 2 (mTORC2) has been implicated as a key regulator of glioblastoma cell migration. However, the roles of mTORC2 in the migrational control process have not been entirely elucidated. Here we elaborate that active mTORC2 is crucial for GBM cell motility. Inhibition of mTORC2 impaired cell movement and negatively affected microfilaments and microtubules’ functions. We also aimed to...

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Literature Corpus work: 919204a4-1848-575d-9867-105062b319cb
DOI: 10.1101/2022.10.12.511677

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