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Article

Molecular pathways: P-Rex in cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2013

Pandiella Atanasio, Montero Juan Carlos

Abstract excerpt

P-Rex proteins are Rho/Rac guanine nucleotide exchange factors that participate in the regulation of several cancer-related cellular functions such as proliferation, motility, and invasion. Expectedly, a significant portion of these actions of P-Rex proteins must be related to their Rac regulatory properties. In addition, P-Rex proteins control signaling by the phosphoinositide 3-kinase (PI3K) route by...

Read the complete abstract on PubMed

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Share to Cell Movement
Share to Cell Proliferation
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Guanine Nucleotide Exchange Factors

Share to Molecular Targeted Therapy

Share to Oncogene Protein v-akt

Share to PTEN Phosphohydrolase

Share to TOR Serine-Threonine Kinases

Source

Identifiers

PMID: 23753921
DOI: 10.1158/1078-0432.CCR-12-1662

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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