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Article

Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2.

Science (New York, N.Y.) - 21 Oct 2016

Peng Wei, Shen Huaizong, Wu Jianping, Guo Wenting, Pan Xiaojing, Wang Ruiwu, Chen S R Wayne, Yan Nieng

Abstract excerpt

RyR2 is a high-conductance intracellular calcium (Ca2+) channel that controls the release of Ca2+ from the sarco(endo)plasmic reticulum of a variety of cells. Here, we report the structures of RyR2 from porcine heart in both the open and closed states at near-atomic resolutions determined using single-particle electron cryomicroscopy. Structural comparison reveals a breathing motion of the overall cytoplasmic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27708056
DOI: 10.1126/science.aah5324

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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