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Article

Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders.

Nature communications - 15 Sept 2024

Miotto Marco C, Reiken Steven, Wronska Anetta, Yuan Qi, Dridi Haikel, Liu Yang, Weninger Gunnar, Tchagou Carl, Marks Andrew R

Abstract excerpt

Heart failure, the leading cause of mortality and morbidity in the developed world, is characterized by cardiac ryanodine receptor 2 channels that are hyperphosphorylated, oxidized, and depleted of the stabilizing subunit calstabin-2. This results in a diastolic sarcoplasmic reticulum Ca2+ leak that impairs cardiac contractility and triggers arrhythmias. Genetic mutations in ryanodine receptor 2 can also cause...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39278969
DOI: 10.1038/s41467-024-51791-y
PMCID: PMC11402997

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