Article

The structure of the humanised A33 Fab C226S variant, an immunotherapy candidate for colorectal cancer

2022-06-21

Abstract excerpt

Colorectal cancer (CRC) causes the second highest cancer-related deaths worldwide. The human A33 antigen is a validated immunotherapy target, which is homogeneously expressed in 95% cases of primary and metastatic colorectal cancers. In this article, we report the structure of a humanised antigen-binding fragment A33 (A33 Fab), a therapeutic antibody candidate, in two different crystal forms. Insights into the str...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f7a68bd4-f95f-5c4a-8580-3bc8daca7c0a
DOI: 10.1101/2022.06.21.497004

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The structure of the humanised A33 Fab C226S variant, an immunotherapy candidate for colorectal cancerDOI 10.1101/2022.06.21.497004Read

A novel human monoclonal antibody specific to the A33 glycoprotein recognizes colorectal cancer and inhibits metastasisSemantic proximity Read

Redesigning An Antibody H3 Loop by Virtual Screening of A Small Library of Human Germline-Derived SequencesSemantic proximity Read

The human A33 antigen is a transmembrane glycoprotein and a novel member of the immunoglobulin superfamilySemantic proximity Read

X-ray Structures of the Antigen-binding Domains from Three Variants of Humanized anti-p185HER2 Antibody 4D5 and Comparison with Molecular ModelingSemantic proximity Read

Structure-based humanization of a therapeutic antibody for Multiple MyelomaSemantic proximity Read

Construction, affinity maturation, and biological characterization of an anti-tumor-associated glycoprotein-72 humanized antibody.Semantic proximity Read

Minimizing immunogenicity of the SDR-grafted humanized antibody CC49 by genetic manipulation of the framework residues.Semantic proximity Read

Principles of mucin structure: implications for the rational design of cancer vaccines derived from MUC1-glycopeptidesSemantic proximity Read

Structural insights into epitope-paratope interactions of monoclonal antibody targeting CEACAM5-expressing tumorsSemantic proximity Read

<em>In Silico</em> Design of a Chimeric Humanized L-Asparaginase.Semantic proximity Read

Characterization and molecular modeling of a highly stable anti-Hepatitis B surface antigen scFv.Semantic proximity Read

C6: A Monoclonal Antibody Specific for a Fibronectin Epitope Situated at the Interface between the Oncofoetal Extra-Domain B and the Repeat III8.Semantic proximity Read