Article
Construction, affinity maturation, and biological characterization of an anti-tumor-associated glycoprotein-72 humanized antibody.
The Journal of biological chemistry - 17 Mar 2006
Yoon Sun Ok, Lee Tae Sup, Kim Sang Jick, Jang Myung Hee, Kang Young Jun, Park Jae Hyun, Kim Keun-Soo, Lee Hyun Sil, Ryu Chun Jeih, Gonzales Noreen R, Kashmiri Syed V S, Lim Sang Moo, Choi Chang Woon, Hong Hyo Jeong
Abstract excerpt
The tumor-associated glycoprotein (TAG)-72 is expressed in the majority of human adenocarcinomas but is rarely expressed in most normal tissues, which makes it a potential target for the diagnosis and therapy of a variety of human cancers. Here we describe the construction, affinity maturation, and biological characterization of an anti-TAG-72 humanized antibody with minimum potential immunogenicity. The...
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