Article

Structure-based humanization of a therapeutic antibody for Multiple Myeloma

2023-09-29

Abstract excerpt

The optimal efficacy of xenogeneically generated proteins intended for application in humans requires that their own antigenicity be minimized. This necessary adaptation of antibodies to a humanized version poses challenges since modifications even distant from the binding sites can greatly influence antigen recognition and this is the primary feature that must be maintained during all modifications. Current strat...

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Literature Corpus work: 4db2d247-d5f3-5a99-84c3-54ee4f6a4565
DOI: 10.1101/2023.09.27.559758

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