Article
C6: A Monoclonal Antibody Specific for a Fibronectin Epitope Situated at the Interface between the Oncofoetal Extra-Domain B and the Repeat III8.
PloS one - 1 Jan 2016
Ventura Elisa, Cordazzo Cinzia, Quarto Rodolfo, Zardi Luciano, Rosano Camillo
Abstract excerpt
BACKGROUND: Fibronectin (FN) is a large multidomain molecule that is involved in many cellular processes. Different FN isoforms arise from alternative splicing of the pre-mRNA including, most notably, the FN isoform that contains the "extra-domain-B" (ED-B). The FN isoform containing ED-B (known as B-FN) is undetectable in healthy adult tissues but is present in large amounts in neoplastic and foetal tissues as...
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