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Article

The human A33 antigen is a transmembrane glycoprotein and a novel member of the immunoglobulin superfamily

21 Jan 1997

Abstract excerpt

The mAb A33 detects a membrane antigen that is expressed in normal human colonic and small bowel epithelium and > 95% of human colon cancers. It is absent from most other human tissues and tumor types. The murine A33 mAb has been shown to target colon cancer in clinical trials, and the therapeutic potential of a humanized antibody is currently being evaluated. Using detergent extracts of the human colon carcinoma...

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PMID: 9012807
DOI: 10.1073/pnas.94.2.469

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