Article

Structural insights into epitope-paratope interactions of monoclonal antibody targeting CEACAM5-expressing tumors

2023-08-11

Abstract excerpt

<title>Abstract</title> <p>Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) are overexpressed in some tumor types. The antibody-drug conjugate, tusamitamab ravtansine, specifically recognizes the A3-B3 domains of human CEACAM5 (hCEACAM5). To understand this specificity, we mapped the epitope-paratope interface between the A3-B3 domains of hCEACAM5 (hCEACAM5<sub>A3 − B3</sub>) and the antigen-bin...

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Literature Corpus work: e46a830a-292f-51d3-b433-49cbadfc909e
DOI: 10.21203/rs.3.rs-3235785/v1

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