Article

<em>In Silico</em> Design of a Chimeric Humanized L-Asparaginase.

2023-01-30

Abstract excerpt

Acute lymphoblastic leukemia (ALL) is the most common cancer among children worldwide, characterized by an overproduction of undifferentiated lymphoblasts in the bone marrow. The treatment of choice for this disease is the enzyme L-asparaginase (ASNase) from bacterial sources. ASNase hydrolyzes circulating L-asparagine in plasma, leading to starvation of leukemic cells. The ASNase formulations of E. coli and E. ch...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ac8e3940-5e03-5d69-a7f7-5fb7d9e4ccd4
DOI: 10.20944/preprints202301.0537.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<em>In Silico</em> Design of a Chimeric Humanized L-Asparaginase.DOI 10.20944/preprints202301.0537.v1Read

Fluorescence-Activated Cell Sorting of Human l-asparaginase Mutant Libraries for Detecting Enzyme Variants with Enhanced Activity.Semantic proximity Read

Discovery of human-like L-asparaginases with potential clinical use by directed evolutionSemantic proximity Read

Structural and functional diversity of asparaginases: Overview and recommendations for a revised nomenclatureSemantic proximity Read

<i>In Silico</i> -Driven Engineering of <i>Halomonas elongata</i> L-Asparaginase: Towards Enhanced Proteolytic Resistance in Lymphoblastic LeukemiaSemantic proximity Read

<scp>l</scp> -Asparaginase as a new molecular target against leishmaniasis: insights into the mechanism of action and structure-based inhibitor designSemantic proximity Read

Studies on Deimmunization of Antileukaemic L-Asparaginase to have Reduced Clinical Immunogenicity--An in silico Approach.Semantic proximity Read

Structural and biochemical properties of L‐asparaginaseSemantic proximity Read

Possible mechanism of metabolic and drug resistance with L-asparaginase therapy in childhood leukaemiaSemantic proximity Read

Mutations in asparaginase II from E. coli and implications for inactivation and PEGylation.Semantic proximity Read

Identification and Structural Analysis of an l-Asparaginase Enzyme from Guinea Pig with Putative Tumor Cell Killing PropertiesSemantic proximity Read

Structures of Apo and Product-Bound Human <scp>l</scp>-Asparaginase: Insights into the Mechanism of Autoproteolysis and Substrate HydrolysisSemantic proximity Read

Asparaginase-Phage P22 Nanoreactors: Toward a Biobetter Development for Acute Lymphoblastic Leukemia TreatmentSemantic proximity Read