Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Minimizing immunogenicity of the SDR-grafted humanized antibody CC49 by genetic manipulation of the framework residues.

Molecular immunology - 1 Oct 2003

Gonzales Noreen R, Padlan Eduardo A, De Pascalis Roberto, Schuck Peter, Schlom Jeffrey, Kashmiri S V S

Abstract excerpt

The murine mAb CC49 specifically recognizes a tumor-associated glycoprotein (TAG)-72, which is expressed on the majority of human carcinomas. This Ab has potential applications in the diagnosis and treatment of human carcinomas. However, patients receiving murine CC49 generate human anti-murine A...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies
Share to Antibodies, Neoplasm
Share to Antigens, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CHO Cells

Share to Cricetinae

Share to Genetic Variation

Share to Glycoproteins

Source

Identifiers

PMID: 14522015
DOI: 10.1016/s0161-5890(03)00166-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14522015-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Minimizing immunogenicity of the SDR-grafted humanized antibody CC49 by genetic manipulation of the framework residues.PMID 14522015Read ↗

Development of a minimally immunogenic variant of humanized anti-carcinoma monoclonal antibody CC49.Semantic proximity Read ↗

Effects of humanization and gene shuffling on immunogenicity and antigen binding of anti-tag-72 single-chain FvsSemantic proximity Read ↗

Construction, affinity maturation, and biological characterization of an anti-tumor-associated glycoprotein-72 humanized antibody.Semantic proximity Read ↗

Humanization of the anti-CD18 antibody 6.7: an unexpected effect of a framework residue in binding to antigen.Semantic proximity Read ↗

Grafting of "abbreviated" complementarity-determining regions containing specificity-determining residues essential for ligand contact to engineer a less immunogenic humanized monoclonal antibody.Semantic proximity Read ↗

A universal combinatorial design of antibody framework to graft distinct CDR sequences: a bioinformatics approach.Semantic proximity Read ↗

Humanization of Predicted T-Cell Epitopes Reduces the Immunogenicity of Chimeric Antibodies: New Evidence Supporting a Simple MethodSemantic proximity Read ↗

Augmented Binary Substitution: Single-pass CDR germ-lining and stabilization of therapeutic antibodies.Semantic proximity Read ↗

Guided selection of a pan carcinoma specific antibody reveals similar binding characteristics yet structural divergence between the original murine antibody and its human equivalent.Semantic proximity Read ↗

“Superhumanized” Antibodies: Reduction of Immunogenic Potential by Complementarity-Determining Region Grafting with Human Germline Sequences: Application to an Anti-CD28Semantic proximity Read ↗

Structure guided homology model based design and engineering of mouse antibodies for humanizationSemantic proximity Read ↗

Directed Evolution of Stabilized Monomeric CD19 for Monovalent CAR Interaction Studies and Monitoring of CAR-T Cell Patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.