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Luteolin antagonises human 5-HT3A receptor function through a non-competitive and voltage-independent mechanism

2026-08-29

Abstract excerpt

<title>Abstract</title> <p> Background The 5-hydroxytryptamine type 3A (5-HT3A) receptor is a ligand-gated ion channel that mediates fast excitatory serotonergic signaling and plays a key role in emesis and gastrointestinal sensory transmission. 5-HT3A receptor antagonists are of substantial therapeutic interest for the management of chemotherapy-induced nausea and vomiting and irritable bowel syndrome, yet the...

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Literature Corpus work: f7938ed3-88f9-523f-a3ec-50602afb2eee
DOI: 10.21203/rs.3.rs-10768265/v1

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