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Article

Identification of a domain affecting agonist potency of meta-chlorophenylbiguanide in 5-HT3 receptors.

European journal of pharmacology - 12 Mar 1999

Mochizuki S, Miyake A, Furuichi K

Abstract excerpt

The pharmacological properties of rat and human 5-HT3 receptors expressed in Xenopus oocytes were assessed using a two-electrode voltage clamp technique. Meta-chlorophenylbiguanide (mCPBG), a 5-HT3 receptor-selective agonist, elicited typical current responses in both rat and human 5-HT3 receptor-expressing oocytes. However, the EC50 value for rat 5-HT3 receptors was 13-fold lower than for human 5-HT3 receptors....

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Source

Identifiers

PMID: 10204690
DOI: 10.1016/s0014-2999(99)00058-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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