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Article

Identification of ginsenoside interaction sites in 5-HT3A receptors.

Neuropharmacology - 1 Mar 2007

Lee Byung-Hwan, Lee Jun-Ho, Lee Sang-Mok, Jeong Sang Min, Yoon In-Soo, Lee Joon-Hee, Choi Sun-Hye, Pyo Mi Kyung, Rhim Hyewhon, Kim Hyoung-Chun, Jang Choon-Gon, Lee Byoung-Cheol, Park Chul-Seung, Nah Seung-Yeol

Abstract excerpt

We previously demonstrated that 20(S)-ginsenoside Rg(3) (Rg(3)), one of the active components of Panax ginseng, non-competitively inhibits 5-HT(3A) receptor channel activity on extracellular side of the cell. Here, we sought to elucidate the molecular mechanisms underlying Rg(3)-induced 5-HT(3A) receptor regulation. We used the two-microelectrode voltage-clamp technique to investigate the effect of Rg(3) on...

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Identifiers

PMID: 17257631
DOI: 10.1016/j.neuropharm.2006.12.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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