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Naturally occurring variations in the human 5-HT3A gene profoundly impact 5-HT3 receptor function and expression.

Pharmacogenetics and genomics - 1 Apr 2007

Krzywkowski Karen, Jensen Anders A, Connolly Christopher N, Bräuner-Osborne Hans

Abstract excerpt

BACKGROUND: The serotonin [5-hydroxytryptamine (5-HT)]-gated ion channel 5-HT3 is involved in the mediation of postoperative and radiotherapy/chemotherapy-induced nausea/emesis and in irritable bowel syndrome. It has also been suggested to play a role in various psychiatric diseases. Five naturally occurring single nucleotide polymorphisms leading to amino acid changes have been identified in the human 5-HT3A...

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Identifiers

PMID: 17496724
DOI: 10.1097/FPC.0b013e3280117269

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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