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Article

Subunit-dependent inhibition and potentiation of 5-HT3 receptor by the anticancer drug, topotecan.

Journal of neurochemistry - 1 Apr 2013

Nakamura Yukiko, Ishida Yusuke, Yamada Takahiro, Kondo Makoto, Shimada Shoichi

Abstract excerpt

The 5-hydroxytryptamine (serotonin, 5-HT) type 3 (5-HT3) receptor belongs to the superfamily of Cys-loop ligand-gated ion channels, and can be either homopentameric (5-HT3A) or heteropentameric (5-HT3AB) receptor. Several modulators are known, which either inhibit or potentiate this channel, but few have any appreciable selectivity between the two subtypes or can modulate one receptor differently to the other. In...

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PMID: 23305320
DOI: 10.1111/jnc.12146

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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