Article

Type I interferon drives a cellular state inert to TCR-stimulation and could impede effective T-cell differentiation in cancer

2024-03-31

Abstract excerpt

Head and neck squamous cell carcinoma (HNSCC) arises from the mucosal epithelium of the oral cavity, pharynx, or larynx and is linked to exposure to classical carcinogens and human papillomavirus (HPV) infection. Due to molecular, immunological, and clinical disparities between HPV+ and HPV-HNSCC, they are recognized as distinct cancer types. While immune checkpoint inhibition (ICI) has demonstrated efficacy in re...

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Literature Corpus work: 2fda87c3-7071-55b9-aa64-74a005678f1a
DOI: 10.1101/2024.03.28.587179

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