Article

A LncRNA-Encoded Interferon Memory Circuit Mediated by MDA5

2025-06-20

Abstract excerpt

<title>Abstract</title> <p>Type I interferon (IFN) signaling is central to antiviral immunity and immune homeostasis, yet the mechanisms that sustain and amplify this response remain unclear. Here, we identify two IFN-inducible Alu-free lncRNAs, lnc-CCDC122 and CATIP-AS2, that amplify IFN responses through the cytosolic RNA sensor MDA5. These lncRNAs are induced downstream of IFNβ but exhibit delayed kinetics rel...

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Literature Corpus work: e030f9db-fdf6-5846-bafe-b1691a546faf
DOI: 10.21203/rs.3.rs-6808513/v1

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