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Article

The Cancer Epigenome: Exploiting Its Vulnerabilities for Immunotherapy.

Trends in cell biology - 1 Jan 2019

Loo Yau Helen, Ettayebi Ilias, De Carvalho Daniel D

Abstract excerpt

During cancer initiation and progression, the somatic epigenome is broadly reprogrammed. This reprogramming can be a consequence of several processes, including altered transcriptional profiles and mutations. In addition, immune cells infiltrating the tumor microenvironment display a reprogrammed epigenome. For instance, tumor infiltrating T cells frequently exhibit an exhausted phenotype characterized by...

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Identifiers

PMID: 30153961
DOI: 10.1016/j.tcb.2018.07.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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