Article

Transcriptomic Integration Reveals a Conserved Inflammatory–Proliferative Paradox in Acquired Resistance to Immune Checkpoint Blockade

2026-04-05

Abstract excerpt

Acquired resistance to immune checkpoint blockade (ICB) is increasingly recognized as an active adaptive process. However, prior studies have typically focused on individual tumor models, limiting the ability to distinguish conserved mechanisms from model-specific observations. Here, we integrated four independent transcriptomic datasets of acquired ICB resistance, spanning human non-small cell lung cancer (NSCLC)...

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Literature Corpus work: e5237386-fa35-58c4-a3fa-bdcbddc8a81f
DOI: 10.64898/2026.04.01.714095

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