Article

Pan-cancer analysis in the real-world setting uncovers immunogenomic drivers of acquired resistance post-immunotherapy

2025-07-07

Abstract excerpt

<h4>ABSTRACT</h4> Immune checkpoint blockade (ICB) has revolutionised cancer therapy, yet resistance — both primary and acquired — remains a significant obstacle, affecting the majority of patients. Here, we leveraged a large-scale, real-world clinicogenomic dataset to systematically explore the molecular underpinnings of ICB resistance in the post-progression setting. Analysing over 5,000 pan-cancer patients wit...

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Literature Corpus work: 413a04a0-fd2d-5522-b54f-529046580ab4
DOI: 10.1101/2025.07.04.663141

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