Article

MYC promotes immune-suppression in TNBC via inhibition of IFN signaling

2021-02-24

Abstract excerpt

Immune checkpoint inhibitor (ICI) treatment has thus far shown limited efficacy in triple-negative breast cancer (TNBC) patients, presumably due to sparse or unresponsive tumor-infiltrating lymphocytes. We reveal a strong correlation between MYC expression and loss of immune signatures in human TNBC. In mouse models of BRCA1-proficient and -deficient TNBC, MYC overexpression dramatically decreased lymphocyte infil...

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Literature Corpus work: ad8093ff-1785-50e0-8c11-970612f902a0
DOI: 10.1101/2021.02.24.432659

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