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Article

Motor neurons with differential vulnerability to degeneration show distinct protein signatures in health and ALS

16 Feb 2015

Abstract excerpt

The lethal disease amyotrophic lateral sclerosis (ALS) is characterized by the loss of somatic motor neurons. However, not all motor neurons are equally vulnerable to disease; certain groups are spared, including those in the oculomotor nucleus controlling eye movement. The reasons for this differential vulnerability remain unknown. Here we have identified a protein signature for resistant oculomotor motor...

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PMID: 25697826
DOI: 10.1016/j.neuroscience.2015.02.013

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