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Article

LCM-seq reveals unique transcriptional adaptation mechanisms of resistant neurons and identifies protective pathways in spinal muscular atrophy.

Genome research - 1 Aug 2020

Nichterwitz Susanne, Nijssen Jik, Storvall Helena, Schweingruber Christoph, Comley Laura Helen, Allodi Ilary, Lee Mirjam van der, Deng Qiaolin, Sandberg Rickard, Hedlund Eva

Abstract excerpt

Somatic motor neurons are selectively vulnerable in spinal muscular atrophy (SMA), which is caused by a deficiency of the ubiquitously expressed survival of motor neuron protein. However, some motor neuron groups, including oculomotor and trochlear (ocular), which innervate eye muscles, are for unknown reasons spared. To reveal mechanisms of vulnerability and resistance in SMA, we investigate the transcriptional...

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Identifiers

PMID: 32820007
DOI: 10.1101/gr.265017.120
PMCID: PMC7462070

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