Article

Single cell transcriptomics identifies master regulators of neurodegeneration in SOD1 ALS motor neurons

2019-03-29

Abstract excerpt

<h4>Background</h4> Bulk RNA-Seq has been extensively utilized to investigate the molecular changes accompanying motor neuron degeneration in Amyotrophic Lateral Sclerosis (ALS). However, due to the heterogeneity and degenerating phenotype of the neurons, it has proved difficult to assign specific changes to neuronal subtypes and identify which factors drive these changes. Consequently, we have utilized single ce...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b49d7438-6b9b-501c-a242-ed157445b17f
DOI: 10.1101/593129

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single cell transcriptomics identifies master regulators of neurodegeneration in SOD1 ALS motor neuronsDOI 10.1101/593129Read

Single-cell transcriptomics identifies master regulators of neurodegeneration in SOD1 ALS iPSC-derived motor neuronsSemantic proximity Read

Single-cell RNA-seq analysis of the brainstem of mutant SOD1 mice reveals perturbed cell types and pathways of amyotrophic lateral sclerosis.Semantic proximity Read

Transcriptional modulation unique to vulnerable motor neurons predicts ALS across species and SOD1 mutations.Semantic proximity Read

iPSC Motor Neurons with Familial ALS Mutations Capture Gene Expression Changes in Postmortem Sporadic ALS Motor NeuronsSemantic proximity Read

Transcriptional modulation unique to vulnerable motor neurons predicts ALS across species and SOD1 mutationsSemantic proximity Read

Gene Expression Signatures of Sporadic ALS Motor Neuron PopulationsSemantic proximity Read

Motor neurons from ALS patients with mutations in C9ORF72 and SOD1 exhibit distinct transcriptional landscapesSemantic proximity Read

RNA-seq analysis of skeletal muscle in motor neurone disease cases and controlsSemantic proximity Read

Transcriptomic profiling of symptomatic and end-stage SOD1-G93A transgenic mice reveals extracellular matrix components as key players in ALS pathogenesisSemantic proximity Read

Single-cell RNA sequencing across isogenic <i>FUS</i> and <i>TARDBP</i> ALS lines reveals a shared early mitochondrial dysfunction unique to motor neuronsSemantic proximity Read

Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1.Semantic proximity Read

Comparison of independent screens on differentially vulnerable motor neurons reveals alpha-synuclein as a common modifier in motor neuron diseases.Semantic proximity Read